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Preclinical studies have shown that this pathway restores glucose metabolism in neurons, reduces A deposition, and preserves cognitive function
Biomed Pharmacother 152:113236 Yaribeygi H, Maleki M, Foroozanmehr B, Kesharwani P, Jamialahmadi T, Karav S, Sahebkar A (2024) Exploring the antioxidant properties of semaglutide: a comprehensive review
Available from: Cadena-Obando D, Ramrez-Rentera C, Ferreira-Hermosillo A, et al
Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected
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