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Mol Cancer Ther 13(12):2876-85, 2014

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Rising popularity of GLP-1 therapies Obesity affects about 40 % of American adults

Elevated lactate concentrations have been demonstrated to increase the NADH/NAD+ ratio, leading to the inhibition of key glycolytic enzymes such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate dehydrogenase, ultimately suppressing both glycolysis and mitochondrial respiration (85)