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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

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With some polls suggesting that as many as 12% of the population have tried GLP-1 medications such as Ozempic, Zepbound, and Wegovy, understanding the significant social and psychological shifts that come with using these drugs is increasingly important