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However, the ability of these mutated receptors to activate arrestin signaling was nearly abolished (Figure 4d), suggesting that these mutated receptors are G protein-biased receptors

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FOXO4-DRI is a senolytic peptide that targets p53, a crucial tumor suppressor that prevents genomic mutations 34

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It also aligns with the observed improvements in cardiometabolic markers seen in clinical trials of incretin-based therapies

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