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Week 1: 50mcg nightly Week 2: 100mcg nightly (if Week 1 tolerated well) Weeks 3-4: 150mcg nightly (if no adverse effects) Weeks 5-8: 200-300mcg nightly (target maintenance dose) Gradual titration helps identify your minimum effective dose while avoiding unnecessary exposure to higher amounts

Here's the general pattern folks tend to experience

Long-term use may also lead to more serious effects, such as bone density loss or eye problems like cataracts

Patients with a personal or family history of thyroid cancer, pancreatitis, or certain endocrine conditions should avoid GLP-1 agonists and explore alternative options