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This hyperactivation downregulates DNA methyltransferases DNMT3A and DNMT3B and impairs autophagy-related gene expression to contribute to ASD pathology [150]

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Such complications may have long-term consequences for maternal health, including higher rates of postpartum depression and possible development of cardiovascular and cognitive disorders later in life [6]

First, significant correlations were observed between serum GPX-3 concentration at diagnosis and both BVAS and VDI at diagnosis, indicating that serum GPX-3 can be a potential biomarker to assess vasculitis activity and damage at diagnosis in patients newly diagnosed with AAV