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Among proteins rhythmic in at least 1 genotype, a surprisingly high number (32.8%) gained rhythmicity in the kidneys of cKOt mice, while only 24.3% proteins lost their rhythmicity, 8.2% had altered rhythmicity, and 34.7% showed unaltered rhythm (Figure 1G)
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Moreover, chronic pain itself has been associated with impairments in attention, memory, and other cognitive domains, as documented in clinical literature on pain-related cognitive dysfunction, which may confound the interpretation of neurobehavioral outcomes in these patient populations (Patel et al., 2025)
