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The available human data suggests significant regression toward baseline after discontinuation, which raises mechanistic questions about whether the compounds produce structural metabolic change or ongoing pharmacological modulation

The extraction step was repeated four times, and the supernatants were combined and lyophilized

Exposing cerebral mitochondria to THC was reported to induce a ten-fold increase in free radical leak and increased H 2 O 2 production [40], while in epithelial cells, THC upregulated inflammation-related genes and downregulated antioxidant-related genes [34]

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