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2020;369:m2440

National Cholesterol Education Program Expert Panel on Detection E, Treatment of High Blood Cholesterol in A: Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III) final report

Bhagavathula AS, Vidyasagar K, Tesfaye W (2021) Efficacy and safety of tirzepatide in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized phase II/III trials

Although high peripheral exposure may be required to obtain the fractional central exposure necessary to illicit a pharmacologic response, insufficient selectivity between MC1R and MC4R activity can lead to peripheral activation of MC1R (142, 143)