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The same covalent mechanism of action was previously demonstrated for another PAM of GLP-1R (i.e., BETP), showing that in addition to C347, BETP also formed a covalent adduct with C438 in the C terminus 27 that is invisible in the current GLP-1R complex structures

Antacids are another over-the-counter medication used to treat heartburn and GERD

However, severe upper abdominal pain that radiates to the back, especially if accompanied by nausea, vomiting, and fever

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