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What would move this position is: a randomised, placebo-controlled trial in a defined population with an objective primary endpoint, a pre-registered protocol, and pharmacovigilance over a clinically meaningful duration

Future research should prioritize multi-omics approaches to dissect subtype-specific molecular mechanisms of GABAergic interneurons and their interactions with other neurotransmitter systems (e.g., glutamatergic, serotonergic pathways)