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Cell Death Discovery (2022) 8(1):427

The Seahorse XF (Extracellular Flux) technology is an advanced analytical platform designed for real-time, label-free, and non-destructive evaluation of cellular bioenergetics

showed that the administration of ipragliflozin led to significant reductions in HbA1c (10% to 7.2%, maintained at approximately 8% for more than 3 years) in a patient with type A IR syndrome treated with metformin and high doses of insulin (9)

See the below from a Genetic Engineering and Biotechnology News story from 2013: The statement came less than two years after Tranzyme went public, and less than two months after the company pulled the plug on a Phase IIb study on the effects of three-times-daily dosing of its lead drug candidate, TZP-102 in patients with diabetes who have gastroparesis