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Some have argued that obesity is a severely under-treated condition, despite its high prevalence, comorbidity with many physical and mental health disorders, and associated mortality and societal cost 246

The gap between effective dose and optimal dose comes down to three variables most protocols overlook entirely: hepatocyte first-pass metabolism rates, blood-brain barrier saturation kinetics, and whether the study population has pre-existing synaptic deficits or intact baseline connectivity

J Toxicol Sci

Consequently, for patients with T2DM and CVD, GLP-1 RAs with a proven CV benefit are preferred in the guidelines