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130,131 In the brain, there are two primary pathways for Wnt signalling: (1) -catenin-dependent stabilized canonical signalling and (2) -catenin-independent noncanonical signalling

4 There is minimal data to reflect the risk of appendicitis with Tirzepatide, but one clinical study depicted appendicitis several months after starting Semaglutide, a GLP-1 receptor agonist