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Compared to a healthy microenvironment, characteristics of a tumor microenvironment can include reduced oxygen concentration which ultimately leads to hypoxia, more acidic pH, remodelling of the ECM and the presence of a plethora of cells which activate inflammatory and immune responses, promote angiogenesis, and support the structure of the solid tumor (Fernando et al., 2021

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Patients may also have an increased risk of developing thyroid tumors

We assessed the reproducibility of the findings in a separate cohort of patients with T2DM from non-overlapping time periods