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The global sensitivity analysis also confirmed the importance of the redox cycle between SQ . and H 2 Q ( R 4 ), showing that the reverse rate constant, k m4 (SQ . reformation), was the second most sensitive (main interactions) with respect to model OCR and therefore ROS production, suggesting auto-oxidation is an essential part of the doxorubicin redox mechanism

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The role of adipose tissue in the pathogenesis of type 2 diabetes and cardiovascular diseases is well known [12] and the recent spurt in drugs that cause a significant reduction in adipose tissue together with a significant reduction in CV risk, has brought renewed attention [13,14,15]