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In the DPP-4/Diprotin A co-crystal structure (PDB ID 1nu8), the peptide bond between the second and third residues is not cleaved after formation of the tetrahedral intermediate, wherein the sidechain of the catalytic serine (Ser630) is covalently linked to the carbonyl carbon atom Pro2

Niacinamide : brightening vitamin that is common in skincare due to its anti-inflammatory capabilities (to soothe redness and irritation) and fades dark spots

Direct evolution allows for the creation of peptide sequences that may not exist in nature, providing access to a vast sequence space beyond what is found in biological sources

Natural color variations may occur