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This review article examines the translational evolution of glucagon-like peptide-1 receptor agonists (GLP-1RAs), tracing their progression from the discovery of exendin-4 in Gila monster venom to long-acting peptide analogues and the first orally delivered peptide therapy, oral semaglutide

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To confirm the expression of LMNA in the transgenic fish, RT-qPCR was conducted by using samples obtained from 7-dpf larvae and 9-month-old F1 adult transgenic fish

The primary endpoint was a change in HbA1c from baseline to 24 weeks, and secondary endpoints included a change in HbA1c and body weight at 36 weeks