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This finding is consistent with the broader observation that GHS-R1a receptors are expressed in multiple tissues beyond the pituitary, including kidney, heart, and immune cells, suggesting pleiotropic protective functions

Overall, with appropriate patient selection, dosing, and monitoring (periodic IGF-1 testing, glucose monitoring in at-risk individuals, clinical assessment), Sermorelin appears to have a favorable benefit-to-risk profile for addressing GH deficiency or age-related GH decline

Strategies to increase nitric oxide signalling in cardiovascular disease