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Since vitamin D3 is primarily synthesized by the body through exposure to sunlight, its intake may be limited in winter or in people who spend little time outdoors

NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994