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10.1016/s0140-6736(07)61380-4 30 MocchegianiE.GiacconiR.CostarelliL

The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose

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*Some of the vision changes may be due to other causes (e.g., diabetic eye disease progression, rapid glycaemic control, weight loss effects) rather than directly due to semaglutide itself.