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Maintain adequate nutrition: Ensure sufficient carbohydrate, protein, and overall caloric intake to support research protocol Assess joint and neurological symptoms: Monitor for swelling, carpal tunnel symptoms, or other adverse effects regularly Periodic biomarker assessment: Re-check glucose, lipids, and metabolic markers at mid-point and end of protocol Plan discontinuation protocol: Gradually reduce dosing over 1-2 weeks at research conclusion rather than abrupt cessation Post-research assessment: Verify that all parameters (glucose, lipids, metrics, symptoms) return to baseline after discontinuation Conclusion IGF-1 LR3 has a generally favourable safety profile when used in research with appropriate doses, duration, and monitoring protocols

doi: 10.1515/hsz-2016-0336 38 PantopoulosKPorwalSKTartakoffADevireddyL

NAD+ is naturally acidic and can cause significant injection site irritation

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