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Internal standard mix (final concentration 0.5 g ml 1 ) included: N-palmitoyl-d31- d -erythro-sphingosine (C16-d31 ceramide), pentadecanoic-d29 acid (15:0-d29 free fatty acid (FFA)), heptadecanoic-d33 acid (17:0-d33 FFA), eicosanoic-d39 acid (20:0-d39 FFA), tetradecylphosphatidylcholine-d42 (14:0-d29 LPC-d13), 1-palmitoyl(d31)-2-oleyl- sn -glycero-3-phosphatidylcholine (16:0-d3118:1 PC), 1-palmitoyl(d31)-2-oleyl- sn -glycero-3-phosphoethanolamine (16:0-d3118:1 PE), 1-palmitoyl-d312-oleoyl- sn -glycero-3-[phospho-rac-(1-glycerol)] (16:0-d3118:1 PG), 1-palmitoyl-d312-oleoyl- sn -glycero-3-phosphoinositol (16:0-d3118:1 PI), N-palmitoyl(d31)- d -erythro-sphingosylphosphorylcholine (16:0-d31 SM), glyceryl-tri(pentadecanoate-d29) (45:0-d87 TAG), glyceryl-tri(hexadecanoate-d31) (48:0-d93 TAG) (all from Avanti Polar Lipids)
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16,27 Efficacy in children and adolescents Liraglutide 3 mg daily for one year was well tolerated in adolescents with obesity and resulted in a 4.6% reduction in body mass index (BMI) compared with placebo
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