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Taking account of the mechanisms of ferroptosis, GSH-depleted methods have been extensively exploited for antitumor therapy based on GSH-enhanced GPX4 inactivity and LPO accumulation

Quiros M, Nusrat A (2014) RhoGTPases, actomyosin signaling and regulation of the epithelial Apical Junctional Complex

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The serine synthesis pathway is mainly supplied by glucose-derived 3-phosphoglycerate, which is converted into 3-phosphohydroxypyruvate by the action of phosphoglycerate dehydrogenase, which also converts NADH into NAD +