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Research published in peer-reviewed journals has explored B12-conjugated GLP-1 agonists specifically to test whether B12 attachment reduces central nervous system penetration while preserving peripheral metabolic effects

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After Au NPs exposure in four cell lines, the cellular response depends on the NP size, for the reason that 1.4 nm NPs cause cell death by necrosis whereas 1.2 nm NPs cause programmed cell death by apoptosis (Pan et al., 2007)