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A randomized clinical trial published in May 2026 in The Lancet investigated whether semaglutide, a GLP-1 peptide that acts as a GLP-1 receptor agonist and is approved for obesity treatment, was associated with changes in alcohol consumption among adults living with both obesity and alcohol use disorder

10.2337/diab.46.5.824 28 FriasJ

Patients who experience appetite suppression as an unwanted side effect during early treatment often find that injecting before bed minimizes their awareness of reduced hunger signals while they sleep