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Studies have shown how its use in mitochondria isolated from rodent brains and subjected to Ca 2+ -induced mPTP conferred protection from mitochondrial swelling and membrane depolarization 49 and prevented Cyt C release and cardiolipin peroxidation 54 via mPTP inhibition (Fig

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doi: 10.1038/nature21363 4 FurmanDCampisiJVerdinECarrera-BastosPTargSFranceschiCet al