Interestingly, most of the pharmacological treatment used in BD showed to increase IL-22, so the efficacy of these drugs may also be in relation with changes in this immune altered response [203]
Free radicals are unstable molecules that can damage cells, proteins, and DNA, leading to various health issues and accelerated aging
Zhang L., Wang S., Yang M., et al., Design, Synthesis and Bioevaluation of 3Oxo6Aryl2,3Dihydropyridazine4Carbohydrazide Derivatives as Novel Xanthine Oxidase Inhibitors, Bioorganic & Medicinal Chemistry 27 (2019): 18181823, 10.1016/j.bmc.2019.03.027
The methionine component is mildly acidic in solution, which compounds the irritation if it's deposited in a concentrated bolus rather than diffusing gradually through the fat layer