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These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

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Muscle tone may improve as lean mass increases alongside continued fat reduction

Formulation and characterization of LNP LNP was generally comprised of 4 lipid components, i.e., ionizable lipid D-Lin-MC3-DMA (MCE, NJ, USA), distearoylphosphatidylcholine (DSPC), cholesterol and DMG-PEG 2k (Millipore Sigma, St