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Increasing recognition that obesity is a chronic disease requiring long-term management makes medications like Wegovy a crucial part of treatment strategies

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The FDA approved tirzepatide under the brand name Zepbound for chronic weight management in adults with obesity or overweight with at least one weight-related condition, alongside a reduced-calorie diet and increased physical activity

Development of GLP-1 receptor agonists The most important strategy to develop compounds with extended in vivo half-life of GLP-1 was by making DPP-4 resistant GLP-1 receptor agonists