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When considering the use of viral vectors in NDDs, some important considerations include balancing tissue-specificity, immunogenicity, packaging limits, and ability to penetrate the BBB

Twenty years on: the impact of fragments on drug discovery

Fuhrmann found that the content of NCOA4 in macrophages decreased under hypoxic conditions, increasing intracellular ferritin content, and thereby enhancing macrophage resistance to ferroptosis [69]