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65 AbenavoliLScarpelliniEColicaCBoccutoLSalehiBSharifi-RadJet al

As a full opioid agonist, it helped stabilize individuals and reduce mortality, but strict regulations and stigma kept it out of reach for many

214,215,216,217 Additionally, sensory neurons in the dorsal root ganglia (DRG) exhibit altered phenotypes, such as reduced neurofilament synthesis, endoplasmic reticulum stress, and changes in key plasticity molecules, such as growth-associated protein 43 (GAP43) and heat shock proteins, leading to mitochondrial dysfunction and loss of peripheral nerve function