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Mini-proinsulin and mini-IGF1: homologous protein sequences encoding non-homologous structures

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A range of histopathological and oxidative-stress-related alterations in cerebral tissue were observed

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Similarly, oxidative stress states such as sepsis and critical illness can predispose to pyroglutamate accumulation due to increased GSH demand driven by elevated reactive oxygen species production [65]

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This multifaceted disruption impairs the BBBs normal homeostatic roles and directly influences neural activity

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