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It took a while to figure out what was going on, but when they reduced her B12 dose to 250mcg three times a week and had her take it in the late morning (when kidneys work best), her symptoms improved and her kidney function stabilized

But for patients with known Hashimoto's, that's insufficient

The table lists fatigue or energy shifts beginning one to three weeks after stopping and lasting two to eight weeks, attributing them to metabolic adjustment and reduced satiety signaling

It was designed to treat obesity by targeting peripheral receptors, but some researchers believe it might actually exert its effects through CB1 receptors in the central nervous system 15