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An innovative approach to using IGF signalling pathways to target cancer is to use them to direct therapies to the tumour, for example, they can be conjugated to nanoparticles to enhance targeting and penetration of the tumour (Zhou et al., 2015)

The FDA has also raised concerns about compounded GLP-1 products, including dosing errors, improper storage during shipping, fraudulent products, adverse event reports, and the use of semaglutide salt forms that should not be used for compounding

J Biol Chem 266: 2897-2902, 1991

As with much of the rare disease field, rare vascular disease trials face the same structural challenge: patient populations are small and scattered across countries, making cross-border collaboration essential rather than optional