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Research reported that the higher the concentration of ascorbate in blood is, the greater the time it is required to initiate lipid peroxidation with no pro-oxidant effects, even in ascorbate serum concentrations of 5 mM achievable only parenterally (Frei et al., Recycling mechanisms To prevent the loss of intracellular concentrations of ascorbate and other antioxidant molecules such as glutathione, cells have recycling mechanisms formed by exogenous antioxidants and the endogenous antioxidant system