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Melatonin improves oxidative stress-induced mitochondrial dysfunction and metabolic reprogramming in aging HGL5 cells We investigated melatonins effects on oxidative stress and mitochondrial function in HGL5 cells using fluorescent dyes (CellROX, DCFH-DA, and MitoSOX)

The emerging research on MOTS-c as another mitochondrial peptide adds additional options for researchers designing energy-focused stacking protocols

Furthermore, animal studies demonstrate that the microbiota in the gut can alter the neurological aspects of depression (103), such as low-grade immune activation (104), the HPA activity (105), altered tryptophan metabolism (106), and neurotrophic factors (107, 108)

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