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In our study, we assumed that Al bio-exclusion could primary be the strategy to limit the intracellular migration of the metal into roots and thereby reducing phytotoxicity

Blocking this process with FAK kinase inhibitors may stabilize sites of focal adhesions and explain the increase in FAK, paxillin, and dual FAK-paxillin containing focal adhesions we observed following treatment with high nanomolar to low micromolar doses of defactinib

Challenging Cases in Melanoma

In the mITT population, the average change in the number of SSEs from baseline to the end of the study was +0.7 events per month in the pooled groups receiving 1.25 and 1.75 mg doses of BMT, compared to only +0.2 events in the placebo group