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Existing interventional trials are small-scale pilot studies that, while positive, are insufficient to establish definitive efficacy for preventing or treating chronic disease

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Although the recovered PTSD group in the cross-sectional clinical study may share some characteristics with a trauma-exposed non-PTSD group, the inclusion of this critical control groupalongside a no-trauma-exposed control group and a trauma-exposed PTSD groupis essential for disentangling the effects of trauma exposure itself from the pathophysiological processes specific to PTSD