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Mechanism of action: Mounjaro works by mimicking the naturally occurring gut hormones GLP-1 and GIP (sometimes also called gastric inhibitory polypeptide)

These benefits were highlighted in 2019 when the Lancet published a meta-analysis of seven clinical trials showing that these treatments reduced hospital admission by 9%, all-cause mortality by 12% and deaths associated with kidney disease by 17% (Wilding et al., 2021)

In their separate trials, the top licensed doses of Mounjaro and Wegovy produced average reductions of 22.5% (SURMOUNT-1) and 20.7% (STEP UP), though no study has directly compared the three