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TTFD B1 Max - a thiamine derivative in its purest form containing a highly-bioavailable derivative of thiamine (vitamin B1) called TTFD - thiamine tetrahydrofurfuryl disulfide, that has been widely researched in Japan for its therapeutic potential in addressing thiamine insufficiency

It stimulates melanocytes, thus causing increased skin pigmentation, which also has some effect on lipid metabolism responsible for appetite and increasing sex drive

This action has physiological significance because glucagon is the major counter-regulatory hormone to insulin action

Unlike short-term application (up to 30 min), TMAO stimulation for 48 h had minimal effect on ERK1/2 or SMAD3 phosphorylation (Fig