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Heading the list were the long-awaited results of TECOS, which looked at the cardiovascular (CV) safety of Merck & Co's DPP-4 inhibitor Januvia (sitagliptin) and concluded that there was no elevated risk with the drug in patients with established CV disease

However, rodent studies suggest a link to medullary thyroid cancer, leading to contraindications for individuals with a personal or family history of MEN2A or medullary thyroid cancer [13]