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After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin

The output criterion was to observe anywhere between 3 and 100 pulses, where more than 55% of the pulses initiated prior to reaching the middle point of the sigmoid gradient (the point of maximal first derivative, as expected for adaptation to the gradient's first derivative)

He showed no emotion when the judge issued her ruling