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The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class

From Beverly Hills to Marina del Rey, the conversation has moved well beyond the prescription pad and into the aesthetic treatment room

This signaling bias has been meticulously studied mainly in conditions designed to mimic pancreatic GLP-1r signaling

Emilio EJ, Hita-Contreras F, Jimnez-Lara PM, Latorre-Romn P, Martnez-Amat A