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Overall, treatment with semaglutide was associated with a reduction in the studys composite outcomecardiovascular death, nonfatal myocardial infarction or nonfatal strokeof 20% compared to a placebo, and it was linked to a safe and well-tolerated profile. SELECT trial results were published in the New England Journal of Medicine in November
It stimulates lipolysis (breakdown of stored fats) and inhibits lipogenesis (formation of new fat), primarily via activation of -adrenergic and AMP-activated protein kinase (AMPK) pathways
A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinsons disease by increasing expression of BNDF
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