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Proposals for software or advanced tool development should include a development approach anchored in the physics of the problem as well as ways to validate the software against existing test data or accompanied with a plan to test relevant hardware and collect the needed date

Three models were constructed: Model 1 (crude model), Model 2 (adjusted for age and sex), and Model 3 (fully adjusted for potential confounders including BMI, blood pressure, lipid profile, renal function, osteocalcin (OCN), vitamin D levels, HbA1c, statin use, antihypertensive medication use, and smoking status)

The diagnostic challenge lies in the fact that fat mass can obscure the progressive loss of muscle, leading to under recognition when using BMI alone