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Es importante destacar que la RI no debe considerarse una enfermedad en s misma, sino ms bien como un factor de riesgo cardiometablico 12

GHK-Cu is typically studied in topical, injectable, or microneedling applications, and is sometimes combined with peptides like BPC-157 or TB-500 to enhance regenerative outcomes

17,22, This provides a rationale for using GLP-1 together with GIP agonism, as GLP-1 may lower glucose sufficiently to unmask the incretin effect of GIP, while GLP-1 action may overcome the potentiating effect of GIP on GCG secretion

Collectively, our findings in this study elucidated the potential signaling mechanisms underlying SEMA-mediated bloodbrain barrier protection and angiogenesis promotion, highlighting its potential as a TBI therapeutic targeting vascular homeostasis