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Phase 2 randomized controlled trial enrolled 338 adults with a BMI of 30 or higher (or 27 with at least one weight-related comorbidity) and without type 2 diabetes [1]

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The apparent absence of the bone mineral density preservation effect seen with liraglutide in MC4R -deficient patients, unlike in common obesity, underscores the need for vigilant bone health assessment and potential adjunctive interventions in this group

In summary, there is a considerable number of clinical studies reporting the potential benefit of GLP-1RAs for use in cognitive disorders, including dementias and Parkinsons disease, although the majority are observational and can only suggest association