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Nutritional Deficiencies: A lack of essential nutrients like folate, iron, and magnesium can impair fertility and overall health

This happens because hormones like estrogen and testosterone drop, making it harder for the body to burn calories well

12 Overall, melanotic macules tend to be small ( 60 years), sex (male), and regional or distant metastasis, also are predictive of poor prognosis

For example, metabolic disorders like type 2 diabetes involve a complex interplay between pancreatic, hepatic, adipose, and immune cells (187), while cancer progression and drug resistance are increasingly linked to interactions between tumor cells, stromal fibroblasts, immune infiltrates, and endothelial components (188, 189)