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FDA has a more rapid approach for approval of chronic weight management drugs, permitting short phase 3 trials of 52 to 68 weeks without requiring pre-approval cardiovascular outcomes trials (CVOTs) whereas Europe insists on such trials

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Vegetarians and vegans: Since B-12 is primarily found in animal products, these dietary choices may lead to deficiency

Sequence comparison among endogenous hormones, approved drugs and triple agonists revealed that the peptide sequence is conserved in the N-terminal region (residues 49), with variations primarily occurring in the middle region (residues 1021) (Fig